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The disease occurs significantly more frequently in men than in women, with an approximate male-to-female ratio of 2:1, a difference that is thought to be related to sex hormone-mediated modulation of immune responses and viral clearance capacity (38)

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Melanotan I Originally developed for medical purposes, such as treating rare light-sensitive conditions like erythropoietic protoporphyria (EPP), Melanotan I is approved in some contexts under strict medical supervision (e.g., Scenesse)