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Among these, Helicobacter pylori infection is the most important since its prevalence has been estimated worldwide at 48%, despite wide regional discrepancies (Oceania 24% vs Africa 79%) ( Helicobacter pylori as cause of inflammatory gastritis in more of 90% of the cases has become clear ( Helicobacter pylori related gastritis initially involves the superficial layer of antrum mucosa of the stomach with an inflammatory mononuclear and plasma cells infiltrate