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In detail, it up-regulated level of acetylated H3K27 induced by LAC that binds to the glutamate receptor metabotropic 2 (GRM2) promoter and acetylation of the NF-B p65 subunit, which enhanced the transcription of the GRM2 gene encoding mGlu2 receptor in the hippocampus and prefrontal cortex (, )

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Glutathione (GSH) levels were considerably reduced, increasing the ROS/GSH ratio, significantly decreasing the expression of the autophagy protein LC3B and related genes, and substantially increasing the expression of the caspase3 protein and apoptosis-related genes in apoptosis assays

Preclinical research published in Cell and Tissue Research confirmed consistent functional, structural, and biomechanical improvements in muscle injury models across multiple administration routes