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The FTO gene variant (rs9939609) influences how the body stores fat and processes lipids, while MC4R variants (rs17782313) affect appetite regulation and weight loss trajectory

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Lancet Diabetes Endocrinol 6(8):605617 Tuttle KR, Lakshmanan MC, Rayner B, Busch RS, Zimmermann AG, Woodward DB et al (2018b) Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial

Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats