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Week 1: 6 units (0.3 mg) daily Week 2: 8 units (0.4 mg) daily Week 3: 10 units (0.5 mg) daily Week 4: 12 units (0.6 mg) daily During this phase, most patients notice improved sleep and mild energy increases

The choice between them depends on whether appetite control or direct metabolic enhancement is the priority

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Additionally, GIPR agonism in the hindbrain is posited to contribute positively to treatment tolerance, as preclinical studies demonstrate that GIPR agonism in the hindbrain, particularly the area postrema, can attenuate the aversive effects of GLP-1RA by directly suppressing the neural activities underlying aversive behaviors (Fig

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