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In a systematic review of 10 clinical trials in patients with HIV lipodystrophy, tesamorelin was effective in reducing VAT and increasing lean body mass and did not alter subcutaneous adipose tissue (146), and increased GH and IGF-I while insulin and glucose levels are unchanged indicating preservation of insulin sensitivity (147150) ( Table 1 )

It is currently under investigation for obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD)