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6a), in most of the diseases a correlation was observed

A caveat of using these medications is that many have reduced renal clearance due to declining kidney function or are contraindicated and often require careful dose adjustments [11,12,13]

Low-level exposures to heavy metalswhich a healthy body would easily excretebegin to accumulate in tissues and organs

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Lancet Diabetes Endocrinol 3(5):367381 van Bommel EJM, Muskiet MHA, Tonneijck L, Kramer MHH, Nieuwdorp M, van Raalte DH (2017) SGLT2 inhibition in the diabetic kidneyfrom mechanisms to clinical outcome