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PMID: 40315972, PMCID: PMC12354148, DOI: 10.1016/j.cgh.2025.03.006

This is particularly important with tirzepatide, which can reduce oral contraceptive exposure during initiation and dose escalation, potentially requiring backup contraception

(PubMed) Joris PJ, Mensink RP

Understanding why requires understanding what each receptor contributes: GLP-1 receptor activation suppresses appetite through hypothalamic signaling, delays gastric emptying to prolong satiety, improves insulin secretion in response to meals, and reduces postprandial glucose

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Further research on specific antipsychotics are needed to explore pharmacological effects on acyl-carnitines in the future