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In other words, metformin isn't just a glucose-lowering drugit's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems

Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis

It works by adding blood inflow to the brain and enhancing the product of acetylcholine, a neurotransmitter that plays a pivotal part in literacy, memory, and attention

They permanently remove the part of the stomach that produces Ghrelin (the hunger hormone), providing a metabolic reset that lasts

Advantages of an antagonist: Bicuculline and other GABA antagonists

Why is our Gut Microbiome So Important