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Exercise also promotes a healthy microbiome, [4] which can help reduce gut problems from GLP-1s

For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results

doi: 10.1172/jci.insight.173392 76 GavinD

The undigested lactose travels to the large intestine, where it gets fermented by colonic bacteria, producing hydrogen gas, carbon dioxide, methane, short-chain fatty acids, and organic acids

doi: 10.1080/09513590.2023.2254848 [DOI] [PubMed] [Google Scholar] 59.Tate M, Robinson E, Green BD, McDermott BJ, Grieve DJ