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So a large oral dose still puts far less into circulation than a smaller injection

"It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30% of their body weight over two years

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However, pemvidutide showed a NASH reduction signal (reduction in liver fat) in an earlier Phase 1b trial interim analysis

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Available at: [accessed March 2026]. Lincoff AM, et al