The SURMOUNT-5 trial (results published in late 2025) confirmed that tirzepatide (Zepbound) produced approximately 47% greater body weight reduction compared to semaglutide (Wegovy) in adults with obesity
Bottom line Stopping a GLP-1 doesn't automatically mean you'll regain all the weight you've lost or lose every health benefit you've gained
Briyal S, Gulati K, Gulati A
Treatments have been targeting substances one at a time, when the right target was craving, the engine that drives addiction across substances
This does not mean that improving diabetes is bad for the eyes. Quite the opposite: good long-term diabetes control is one of the best ways to reduce retinal damage over time
A better approach is to ask a different question: How do I help my body lose fat while keeping as much muscle, strength, and performance as possible