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6 The phase 2 monotherapy dose-finding trial by Lau and colleagues established that once-weekly cagrilintide up to 4.5 mg produced dose-dependent weight loss about 10.8% at the top dose over 26 weeks with a gastrointestinal side-effect profile (nausea and related symptoms) that is the clinical fingerprint of a gut-slowing, satiating mechanism

Bouayed J, Bohn T

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Infants born to HBsAg-positive mothers are at risk of being infected with hepatitis B virus and becoming chronic carriers.(6,9-11) This risk is especially great if the mother is HBeAg-positive.(13-15) For an infant with perinatal exposure to an HBsAg-positive and HBeAg-positive mother, a regimen combining one dose of Hepatitis B Immune Globulin (Human) at birth with the hepatitis B vaccine series started soon after birth is 85%95% effective in preventing development of the HBV carrier state.(9,15) Regimens involving either multiple doses of Hepatitis B Immune Globulin (Human) alone or the vaccine series alone have 70%90% efficacy, while a single dose of Hepatitis B Immune Globulin (Human) alone has only 50% efficacy.(9,16) Sex partners of HBsAg-positive persons are at increased risk of acquiring HBV infection

Compared to participants with homocysteine levels below 9.0 mol/L, those with levels of 9.011.9 mol/L had a 30% increased risk of cardiovascular death and 40% increased odds of non-cardiovascular death, and those with levels of 12.014.9 mol/L had a 110% increased risk of cardiovascular and 90% increased risk of non-cardiovascular death