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This gastric pentadecapeptide sequence has been one of the most extensively investigated compounds in preclinical research, with studies examining cytoprotective and tissue integrity pathways

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Here two different pharmacological agents known to induce gut permeability (ethanol and AT1002, a Vibrio cholerae zonula occludens toxin hexapeptide) were used to induce transient increase in gut permeability in mice before their exposure to experimental colitis

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