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Li: Loss of lean body mass is a real concern, especially in older adults

Timing Follow-up Marker Blood pressure and resting heart rate Why it matters Adds cardiovascular context during weight loss, medication changes, and hydration shifts

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- It plays a critical antioxidant role inside cells and is used pharmaceutically to treat liver toxicity and drug overdose

Subsequent internal validation on a cohort of 121,578 participants demonstrated high accuracy, with an area under the receiver operating characteristic curve (AUC) of 0.842 ( 5.2 Robust performance and persistent challenges The remarkable performance of DeepDKD is not an isolated phenomenon but is instead reflective of the broader, high-performing potential of ML in DKD risk prediction, as confirmed by a recent systematic review and meta-analysis ( 5.3 Translational challenges and future directions for AI in DKD The promising performance of AI models must be tempered by a clear-eyed assessment of the barriers to their clinical implementation