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Within this framework, LPS and histamine exert a critical priming effect: circulating LPS lowers the inflammatory activation threshold of peripheral tissues, while rumen-derived histamine promotes microvascular dysregulation and lamellar hypoxia

Major diseases such as cancer and cardiovascular ailments can be associated with inflammation caused by oxidative stress

Deficiency in vitamin B6 is commonly linked to malnutrition, alcoholism, malabsorption syndromes, or as an adverse effect of certain medications, such as cyclosporine, hydralazine, cycloserine, penicillamine, isoniazid, levodopa, phenelzine and chemotherapy treatments (, , , )

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It supports antioxidant activity, protecting immune cells from oxidative damage

Lancet 383 , 12501263 (2014)