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Ethical permission was obtained from The Ethics Committee of NUI Maynooth for the use of human serum specimens

Climacteric 15:317319 Villareal DT, Shah K, Banks MR, Sinacore DR, Klein S (2008) Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial

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Beyond its ability to increase the intracellular pool of Ca 2+ , GLP-1 also affects insulin secretion via cAMP-mediated regulation of exocytosis (Figure 6)