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Water Sci Technol

The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function

109 Additionally, metabolites such as 2-hydroxyglutarate, succinate, and fumarate derived from mutations in IDH1/2, FH, and SDH inhibit DNA repair pathways by repressing lysine demethylase KDM4B, resulting in abnormal excessive H3K9 methylation at DNA break sites, impairing recruitment of TIP60 and ATM, reducing end resection, and decreasing recruitment of downstream repair factors

Therefore, early immune modulation contributes to ECM remodelling and spatial and temporal muscle fascia restoration, indicating the potential for hernia repair

Role of neuropoietic cytokines in development and progression of diabetic polyneuropathy: from glucose metabolism to neurodegeneration

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