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In addition, PFOS can induce autophagy activation with increased Beclin and LC3BII expression through reactive oxygen species (ROS)-mediated extracellular signalregulated kinase (ERK) activation, which is followed by impeded autophagic flux, increased lysosomal membrane permeability (LMP), and, consequently, RTC apoptosis

This peptide comprises three functional domains: a photosensitizer (TEP) for reactive oxygen species (ROS) generation, a self-assembly motif (FFG), and a GPX4-targeting sequence (CRApY)

L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)--a randomized multicentre trial