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In this work, the authors were able to counter the increased proton leak and mPTP opening by ubiquinone analogs [336]

Sandborn WJ, Ghosh S, Panes J, Vranic I, Wang W, Niezychowski W, et al

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With regard to depression, we have few and inconclusive studies, although we would like to point out that one study on patients with a major depressive episode, who had a chronic psychiatric disorder (on average, for almost 17 years) and therefore had a poor response to pharmacological treatment, concluded that supplementing standard treatment with NAC has favorable effects by reducing symptoms and improving patients functioning [129]