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Because of its availability, the effect of GHK and GHK-PEG were first tested in histiocytic lymphomacells (U937)

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To test the involvement of NRF2, we bred the Gclc f/f mouse strain with the Nrf2 f/f mouse strain 57,58 and induced a liver-specific double deletion with the AAV-TBG-Cre virus (hereafter referred to as L-DKO) (Fig