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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk complications in patients with type 2 diabetes (UKPDS 33)

Hasler G, Drevets WC, Manji HK, Charney DS

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Supresin de glucagn : Reduce la liberacin de glucagn, una hormona que aumenta la glucosa en sangre, ayudando a prevenir picos glucmicos despus de las comidas

Medication history: prior GLP-1, GIP, insulin, or sulfonylurea use

Staying well-hydrated is equally important, as adequate fluid intake supports proper circulation and temperature regulationespecially relevant given the FDA warnings about dehydration risk with GLP-1-based therapies