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Under stressed conditions, ROS function as secondary messengers which modulate the expression of multiple stress-responsive genes through the activation of various transcription factors

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doi: 10.1136/rmdopen-2018-000870 36 WernerSGVlachouMLangerHEChatelainR

On the other hand, aberrant PPP activity in metabolic disorders like diabetes and metabolic syndrome can exacerbate oxidative stress and contribute to disease pathogenesis