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We therefore conclude that before the place of GLP-1/glucagon co-agonists within the therapeutic armamentarium can be defined, future research efforts need to address the following outstanding questions: What is the optimal balance and receptor potency of GLP-1 and glucagon in a long-acting co-agonist, to minimise adverse effects and to optimise efficacy ( Figure 2 )

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Qiao, W., Li, Z., Liu, W

Chuanbo Zhang and other medical staff from Weifang Mental Health Center for their assistance with subject recruitment, follow-up and blood sample collection