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While each component ideally represents an in-focus neuronal soma, the identification process also captures confounding components which can arise from out-of-focus somata, non-somatic structures (e.g., dendrites or blood vessels), or non-biological sources (e.g., fluctuations in background fluorescence), all of which are considered abnormal signals or artifacts

The FLOW trial demonstrated clear kidney and cardiovascular protection with GLP-1 receptor agonist (GLP-1RA) treatment in individuals with type 2 diabetes and chronic kidney disease (CKD)

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