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In adults with type 2 diabetes, treatment with tirzepatide 5 mg, 10 mg and 15 mg once weekly was associated with superior weight reduction from baseline compared with placebo, semaglutide 1 mg weekly, titrated insulin degludec, titrated insulin glargine and titrated insulin lispro as an add-on to insulin glargine

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Gallbladder disease and gallstones are also possible side effects of Semaglutide

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Importantly, the MHRA SmPC for Mounjaro warns that tirzepatide can reduce the efficacy of oral contraceptive pills due to delayed gastric emptying

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