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In parallel, sHSPs, ranging from approximately 12 to 43 kDa, have emerged as critical modulators of protein aggregation and toxicity in the nervous system (Fig
These thresholds have been developed based on data from GLP-1 clinical trials and real-world safety considerations
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Its well-known adverse events, e.g., interstitial pulmonary fibrosis, seizures, liver veno-occlusive disease, or sinusoidal obstruction syndrome [96] seem to be caused by glutathionyl-tetrahydrothiophene, a metabolite that derives from the irreversible GSH conjugation [97,98]