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IGF-1 can act over its putative receptor (IGF-1R) or it can also bind to the insulin receptor (IR), albeit with less affinity [98100]

*Correspondence: Patrick ODonoghue, [email protected] This article was submitted to Chemical Biology, a section of the journal Frontiers in Chemistry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

More doesn't always mean better, especially if it causes irritation