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TOPI inhibitor-induced SSBs require tyrosyl-DNA phosphodiesterase 1 (TDP1)-mediated excision repair and homologous recombination pathways for repair, so mCRPC tumors harboring HRD may exhibit increased sensitivity to TOPI inhibitor-carrying ADCs 36,37

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Note that the definition for treatment zone is different than with the old coding structure (as explained later)

2019 Aug;35(8):695-700

Increased awareness and regulation of Ozempic promotion on social media platforms are needed to mitigate its non-prescription misuse