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doi: 10.3389/fnut.2025.1642363 Received 06 June 2025 Accepted 17 August 2025 Published 09 September 2025 Volume 12 - 2025 Edited by Kenji Nagao, Ajinomoto (Japan), Japan Reviewed by Ana Beatriz Janurio, Federal University of Pernambuco, Brazil Hiba Hamdar, Plovdiv Medical University, Bulgaria Updates Copyright 2025 Chen, Li, Wang, Liu and Qiu

We hypothesized that oxidation of GSH to glutathione disulfide (GSSG) in the epithelial lining fluid (ELF) of children with severe asthma would contribute to altered airway macrophage (AM) GSH homeostasis and AM cellular dysfunction