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Understanding these mechanisms helps explain why the peptide shows such broad therapeutic potential
LPAR1 and LPAR3 are primary targets
Cause of Low B12 levels Pernicious anaemia vegan diet malabsorption syndromes coeliac sprue Crohn's ulcerative colitis (UC) "food-bound cobalamin malabsorption syndrome" predisposing factors include atrophic gastritis, long term proton pump inhibitor or H2 antagnoist use, chronic alcoholism, gastrectomy/gastric bypass surgery, pancreatic exocrine failure, AIDS myeloma (paraprotein related assay interference) pregnancy combined oral contraceptive pill/HRT pancreatric insufficiency metformin, acute phase situations
Usage Safety: Divide into single-use aliquots post-mixing to completely avoid freeze-thaw cycles
It is best to take it on an empty stomach, at least 30 minutes before or 2 hours after a meal.
dans le cas de maladies susceptibles de diminuer labsorption de la vitamine B12, telles que la maladie de Biermer, de la maladie dImerslund, chez les personnes ayant subi lablation de lestomac ou dune partie de lintestin
