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In particular, DAS and its metabolites have been found to inhibit CYP2E1 activity in vitro (56, 57) and when administered orally at high doses to animals (58, 59)

Ridley and Hall, 1992

Since B12 is also essential for fetal development, particularly the development of the neural tube, low B12 can increase the risk of birth defects if left unaddressed in pregnant women

For these reasons, we hypothesize that resveratrol shortens the chronological life span (CLS) of Saccharomyces cerevisiae due to a pro-oxidant activity

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