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doi: 10.1016/j.ejphar.2022.175175 36 LiuY.ZhangZ.FangY.LiuC.ZhangH

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Always, always start with the lowest effective dose and titrate upwards carefully, observing for any unexpected responses

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A caveat when interpreting our results is that in many cases we treated cells with relatively high doses of agonist in order to establish differences in maximal response

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