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Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]

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whey proteins) serves all the necessary precursors for GSH synthesis and LAB having potential for glutathione biosynthesis could be used successfully for delivering this vital molecule in the human system through a milk or whey based functional fermented food

doi: 10.1016/S2214-109X(21)00448-4