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Application of drugs or chemical products such as anticancer, antibiotic, or pesticide also caused cardiotoxicity effects

These mutations therefore disproportionately affect individuals with ancestry from malaria endemic regions, namely Africa, the Middle East, Southeast Asia, and the Mediterranean

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Xu B, Chibber R, Ruggiero D, Kohner E, Ritter J, Ferro A (2003) Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products