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349 If the ulcers fail to show a 50% reduction after 4 weeks of appropriate management via conventional methods, several advanced therapies, including negative-pressure therapy, growth factor therapy, bioengineered tissue, acellular matrix tissue, stem cell therapy, hyperbaric oxygen therapy, and, most recently, topical oxygen therapy, can be considered

doi: 10.1080/15592294.2020.1786318 13 LeeGRKimSTSpilianakisCGFieldsPEFlavellRA

Vornoli A, Tibaldi E, Gnudi F, Sgargi D, Manservisi F, Belpoggi F, et al

Khacho M, Harris R, Slack RS

Cells lacking TREM2 show impaired energy metabolism reduced mitochondrial quality, and abnormal organelle structure

10.3390/ijms21186554 31 ElbeH.VardiN.EsrefogluM.AtesB.YologluS.TaskapanC