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Principal component analysis (PCA) indicated that Day 30 iHLOs exhibited a protein expression pattern more closely aligned with human liver tissue than HepaRG and HepG2 cells (Fig

DOI:10.1002/14651858.CD005228.pub4 [ Links ] 66

[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Johnston J.B., Israels L.G., Goldenberg G.J., Anhalt C.D., Verburg L., Mowat M.R., Begleiter A

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3.3.2 Iron overload under high glucose promotes ROS generation and triggers ferroptosis HG disrupts iron homeostasis: upregulated TFR1 (iron uptake) and downregulated FTH1 (iron storage) lead to LIP expansion (129, 130)