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In the early 1900s, with the advent of new medical therapies and disease perspectives, novel strategies were employed to promote weight loss including thyroid hormone supplementation, and later, amphetamines [1]

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Proc Natl Acad Sci U S A 2020;117:2995967.PubMedPMC 39

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Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial

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