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Central role of mitochondria in drug-induced liver injury

Mammalian cells have evolved elaborate mechanisms for restoring redox homeostasis and resolving acute inflammatory responses

Favilla V, Russo GI, Privitera S, et al

Molecular dynamics simulations therefore suggest a different behaviour for residue R299 ECL2 , which is stably involved in interactions with the peptide in the GLP-1-RGLP-1G s complex (Extended Data Table 1), and instead interacts with E34 ECD and other residues located at the ECL2 (E294 ECD , D293 ECD and N300 ECD ) in the GLP-1RTT-OAD2G s complex (Extended Data Table 2)

Farmakoterapia nie zastpuje planu leczenia otyoci Analogi GLP-1 mog wspiera redukcj masy ciaa, ale nie powinny by traktowane jako samodzielny, oderwany od reszty terapii sposb leczenia