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Given the importance of the 3' untranslated region (3' UTR) in mRNA stability [31], we next investigated whether SYNCRIP stabilizes SIRT1 mRNA through interaction with the associated 3' UTR using a luciferase reporter assay containing the SIRT1 3' UTR

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Iron is considerably more toxic to cells expressing CYP2E1 than to cells not expressing this enzyme, and it is suspected that low concentrations of iron may act as a protective factor for CYP2E1 -induced injury

And those didnt show any increased risks