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Activated microglia disrupt the blood-brain barrier and induce chemokines and cytokines in a rat in vitro model

It mimics the action of GLP-1, a hormone produced in the intestines that stimulates insulin secretion and suppresses glucagon release

Central to this system is the CLOCK: BMAL1 heterodimer, which binds to E-box sequences in the promoters of clock-controlled genes, activating their rhythmic expression (25)