This indicates that DPP-4i treatment is in some cases attempted before switch to GLP-1 RAs, as the cost of DPP-4is is lower, and GLP-1 RAs (during the period in which this study was conducted) required injections
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PDB-101: diabetes mellitus: liraglutide
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Astic, L., Saucier, D., Coulon, P., Lafay, F
Considering that PPG neurons are projecting neurons that have axons containing GLP1 vesicles in many distinct regions of the brain (Figure 1), it seems likely that GLP1 release and action within the brain is locally restricted and regulated like that of other neurotransmitters and modulators