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Minimal adverse effects observed in preclinical models
41 Based on the results of previous studies, 50,100 and 200mg/kg cinchonine were used in OGTT
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Both therapies have clear contraindications, and a responsible clinic will screen for them before prescribing
The escalation intervals were not arbitrary: each step was separated by several weeks to allow for monitoring of adverse events, biomarker shifts, and weight-loss trends
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