Exosomes contribute to drug resistance in cancer by packaging chemotherapy agents and transporting them to sensitive cells
As cosmetic chemist Colins writes it, "its safety really is beyond any doubt"
In a study on rats (0, 1.8, 3.8, 15 or 175 mg/kg body weight per day), the effects were characterized histologically as an increase in the incidence and severity of hyperplasia, hyperkeratosis, and ulcers and erosions of the squamous mucosa of the forestomach, and as epithelial hyperplasia of the kidney proximal convoluted tubules at 3.8 mg/kg and above
The S2 pocket is larger and binds inhibitors and not substrates
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