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(3) optimizing glycemic control without excessive hypoglycemia (54)
The primary mechanism through which GLP-1RAs induce weight loss is appetite suppression and delayed gastric emptying, mediated via hypothalamic and brainstem pathways [27]
Fasting and postprandial hyperglucagonemia in T2DM patients stimulates glucose production in the liver, leading to hyperglycemia
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Loss of control eating a hallmark of binge episodes was also significantly reduced
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