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This method can potentially lead to higher absorption rates and more immediate benefits

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DM elevates the risk of periodontitis, while periodontitis, in turn, impairs glycemic control and exacerbates diabetic complications (43)

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102,227,228,314,315,316,317 These effects lead to arterial resistance and remodeling, ultimately contributing to renal dysfunction and fibrosis

The risks of renal impairment, volume depletion adverse reactions and urinary tract infection-related adverse reactions increased with worsening renal function [see Warnings and Precautions (5.2)]