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If the pen is already in use and the room temperature stayed between 59 and 86 degrees Fahrenheit, Ozempic is approved for room temperature storage for up to 56 days

Others have step-therapy requirements

Reconstituted semaglutide should be refrigerated at 36-46 degrees Fahrenheit (2-8 degrees Celsius)

These studies found that modest increases in resting heart rate did not translate to increased risk of heart attack, stroke, or other major cardiac events in patients without pre-existing heart disease

Understanding what happens if semaglutide gets warm is essential for patients using Ozempic, Wegovy, or Rybelsus

Its mechanism of action includes stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways