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The 20mg and 30mg vials offer the best value per milligram and are appropriate for extended research programs requiring consistent dosing over multiple weeks

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Commenters suggested that CMS determine the work valuation for each code based not only on surveyed work times, but also the intensity and complexity of the service and relativity to other similar services, rather than basing the work value entirely on time

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Split dosing: Some practitioners split the daily dose into 250 mcg AM and 250 mcg pre-sleep on the rationale that two smaller pulses maintain steadier receptor exposure