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10.1016/j.cell.2022.06.003 28 SunY.ChenP.ZhaiB.ZhangM.XiangY.FangJ.et al (2020)

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Nevertheless, the kinetic data for our mutants and rate constants for ScGrx7 and PfGrx between 10 5 10 6 M 1 s 1 are too slow for a diffusion-controlled reaction and point towards important short-lived enzymesubstrate interactions and rate-limiting re-orientations of the substrate at the enzyme surface

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These interconnected processes are essential to understanding how tissues adapt and maintain structural integrity under changing physiological conditions