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Using a pregnancy mouse model and metabolomics analysis, our findings reveal that fullerenols exposure during pregnancy not only significantly reduced mice placental weight and villi thickness, but also altered the classes and concentrations of metabolites in the mouse placenta

doi: 10.1186/s43556-023-00142-2

With respect to NHR-49 , codon-optimized constructs for full-length NHR-49 and a fragment spanning residues 1155 were cloned into the pET-28a(+) vector (GenScript, Piscataway, NJ)

Research on diet-induced obese mice indicates that fat cell size decreased by approximately 30% and fat volume decreased by around 40%